Histidine biosynthesis, HisF (IPR004651)

Short name: HisF

Overlapping homologous superfamilies

Family relationships


Histidine is formed by several complex and distinct biochemical reactions catalysed by eight enzymes. Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in one family. These enzymes are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes [PMID: 16731983, PMID: 15363855, PMID: 11679715]. HisA is a phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase (EC:, involved in the fourth step of histidine biosynthesis. The bacterial HisF protein is a cyclase which catalyzes the cyclization reaction that produces D-erythro-imidazole glycerol phosphate during the sixth step of histidine biosynthesis. HisF is also known as imidazole glycerol phosphate synthase [PMID: 16142895, PMID: 12795596, PMID: 12417026]. The yeast His7 protein is a bifunctional protein which catalyzes an amido-transferase reaction that generates imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide. The latter is the ribonucleotide used for purine biosynthesis. The enzyme also catalyzes the cyclization reaction that produces D-erythro-imidazole glycerol phosphate, and is involved in the fifth and sixth steps in histidine biosynthesis.

This family describes the histidine biosynthesis protein, HisF.

GO terms

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0000107 imidazoleglycerol-phosphate synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.