Family

Aspartate--ammonia ligase (IPR004618)

Short name: AsnA

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Aspartate--ammonia ligase (asparagine synthetase) EC:6.3.1.1 catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. This family represents one of the two non-homologous forms of aspartate--ammonia ligase found in Escherichia coli. This type is also found in Haemophilus influenzae, Treponema pallidum and Lactobacillus delbrueckii, but appears to have a very limited distribution. The fact that the protein from the H. influenzae is more than 70% identical to that from the spirochete T. pallidum, but less than 65% identical to that from the closely related E. coli, strongly suggests lateral transfer.

AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II aminoacyl-tRNA synthetases. Ammonia-dependent AsnA is not homologous to the glutamine-dependent asparagine synthetase AsnB [PMID: 1346128].

GO terms

Biological Process

GO:0006529 asparagine biosynthetic process

Molecular Function

GO:0004071 aspartate-ammonia ligase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PIRSF
Pfam
CDD
PANTHER
HAMAP