Family

Phosphoribosylglycinamide formyltransferase (IPR004607)

Short name: GART

Overlapping homologous superfamilies

Family relationships

None.

Description

Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis [PMID: 2147474]. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a single domain protein [PMID: 8876651] but in most eukaryotes GART (purN) resides in the C-terminal portion of a large multifunctional protein which also contains GAR synthetase (purD) and aminoimidazole ribonucleotide (AIR) synthetase (purM) activities [PMID: 12450384].

GO terms

Biological Process

GO:0006189 'de novo' IMP biosynthetic process

Molecular Function

GO:0004644 phosphoribosylglycinamide formyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
TIGRFAMs
CDD