Phosphoribosylglycinamide formyltransferase (IPR004607)

Short name: GART

Overlapping homologous superfamilies

Family relationships



Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis [PMID: 2147474]. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a single domain protein [PMID: 8876651] but in most eukaryotes GART (purN) resides in the C-terminal portion of a large multifunctional protein which also contains GAR synthetase (purD) and aminoimidazole ribonucleotide (AIR) synthetase (purM) activities [PMID: 12450384].

GO terms

Biological Process

GO:0006189 'de novo' IMP biosynthetic process

Molecular Function

GO:0004644 phosphoribosylglycinamide formyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.