4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type (IPR004588)

Short name: IspG_bac-typ

Family relationships


This protein previously of unknown biochemical function is essential in Escherichia coli. It has now been characterised as 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, which converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4CPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate in the sixth step of nonmevalonate terpenoid biosynthesis. The family is largely restricted to bacteria, where it is widely but not universally distributed. No homology can be detected between this family and other proteins.

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0016114 terpenoid biosynthetic process

Molecular Function

GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.