DNA recombination/repair protein Rad52 (IPR004585)

Short name: DNA_recomb/repair_Rad52

Overlapping homologous superfamilies


Family relationships


Rad52 was identified in Saccharomyces cerevisiae (Baker's yeast) as a component of the homologous recombination repair pathway and to play an important role in both meiotic and mitotic recombination. The human protein is highly homologous in both structure and function. In the presence of absence of DNA, Rad52 forms ring-shaped oligomers which bind both single and double stranded DNA, stimulating annealing of complimentary DNA strands and promoting ligation of both cohesive and blunt-end fragments. Rad52 may act as a recombination mediator, optimising catalysis of strand exchange by the Rad51 protein.

A C-terminal self-association domain has been identified that mediates formation of higher order oligomers of Rad52 rings. Formation of these oligomers may be important for interaction with more than one DNA molecule [PMID: 12226092].

GO terms

Biological Process

GO:0000730 DNA recombinase assembly
GO:0000724 double-strand break repair via homologous recombination
GO:0045002 double-strand break repair via single-strand annealing

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.