DNA repair protein Rad50, eukaryotes (IPR004584)

Short name: Rad50_eukaryotes

Overlapping homologous superfamilies


Family relationships



RAD50 is involved in DNA double-strand break repair (DSBR), telomere maintenance and meiotic recombination [PMID: 9590181, PMID: 24168161, PMID: 23671188]. The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity [PMID: 15296753, PMID: 15135728]. RAD50 provides ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the MRE11 active site [PMID: 9705271, PMID: 11454871, PMID: 17698079]. This entry represents the eukaryotic Rad50 that is distantly related to the SbcC family of bacterial proteins.

In Saccharomyces cerevisiae, Rad50 forms the MRX complex with Mre11 and Xrs2.

In humans, RAD50 forms the MRN complex with MRE11 and NBN (also known as NBS1). Mutations in the RAD50 gene cause the Nijmegen breakage syndrome-like disorder (NBSLD) [PMID: 19409520]. The genetic variations in the RAD50 gene have been linked to susceptibility to asthma [PMID: 21734400].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0000723 telomere maintenance

Molecular Function

GO:0016887 ATPase activity

Cellular Component

GO:0030870 Mre11 complex
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.