DNA repair protein Rad18, fungi (IPR004580)

Short name: Rad18_fungi

Overlapping homologous superfamilies


Family relationships


During DNA replication, lesion bypass is an important cellular response to unrepaired damage in the genome. In the yeast Saccharomyces cerevisiae (Baker's yeast), Rad6 and Rad18 are required for both the error-free and error-prone lesion bypass mechanisms. The Rad18 gene encodes a RING-finger protein with single-stranded DNA binding activity that interacts with the ubiquitin-conjugating enzyme Rad6.

This entry represents the Rad8 from fungi.

GO terms

Biological Process

GO:0006301 postreplication repair
GO:0006513 protein monoubiquitination

Molecular Function

GO:0003697 single-stranded DNA binding
GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.