DNA repair protein, Rad18 (IPR004580)

Short name: Rad18

Overlapping homologous superfamilies


Family relationships



During DNA replication, lesion bypass is an important cellular response to unrepaired damage in the genome. In the yeast Saccharomyces cerevisiae (Baker's yeast), Rad6 and Rad18 are required for both the error-free and error-prone lesion bypass mechanisms. The RAD18 gene encodes a RING-finger protein with single-stranded DNA binding activity that interacts with the ubiquitin-conjugating enzyme RAD6.

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003684 damaged DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.