8-oxoguanine DNA-glycosylase (IPR004577)

Short name: Ogg1

Overlapping homologous superfamilies

Family relationships



One of the major base lesions induced by oxidative stress is 8-oxoguanine (8-oxoG), one of the oxidised forms of guanine. 8-oxoguanine DNA glycosylase (also known as N-glycosylase/DNA lyase) functions in base excision repair and is responsible for the excision of 8-oxoguanine. It has beta-lyase activity that nicks DNA 3' to the lesion [PMID: 8805338, PMID: 8643552, PMID: 9187114].

GO terms

Biological Process

GO:0006284 base-excision repair

Molecular Function

GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.