CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (IPR004570)

Short name: Phosphatidylglycerol_P_synth

Overlapping homologous superfamilies


Family relationships


CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC:, also known as phosphatidylglycerophosphate synthase, glycerophosphate phosphatidyltransferase and PGP synthase, catalyses the conversion of CDP-diacylglycerol and glycerol-3-phosphate to CMP and 3-(3-phosphatidyl)-glycerol 1-phosphate in the committed step to the synthesis of acidic phospholipids. It is an integral membrane protein. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharomyces cerevisiae (Baker's yeast) YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologues as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.

GO terms

Biological Process

GO:0008654 phospholipid biosynthetic process

Molecular Function

GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.