Apolipoprotein N-acyltransferase (IPR004563)

Short name: Apolipo_AcylTrfase

Overlapping homologous superfamilies

Family relationships



Apolipoprotein N-acyltransferase (Lnt) transfers the acyl group to lipoproteins and is involved in lipoprotein biosynthesis in Gram-negative bacteria. It is an integral membrane protein [PMID: 17416655]. In the last step of lipoprotein maturation, N-acylation by apolipoprotein N-acyltransferase of the plasma membrane is required for recognition of the outer membrane lipoproteins by the Lol system, which transports the lipoproteins from the plasma to the outer membrane [PMID: 15513925]. This is a reverse amidase (i.e. condensation) reaction.

This entry also includes bifunctional apolipoprotein N-acyltransferase/polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 9 [PMID: 7987228, PMID: 11380987].

GO terms

Biological Process

GO:0042158 lipoprotein biosynthetic process

Molecular Function

GO:0016410 N-acyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.