Modification methylase HemK (IPR004556)

Short name: Modification_methylase_HemK

Overlapping homologous superfamilies

Family relationships


The gene hemK from Escherichia coli was found to contribute to haem biosynthesis and originally suggested to be protoporphyrinogen oxidase [PMID: 7883187]. Functional analysis of the nearest homologue in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologues have S-adenosyl-methionine-dependent methyltransferase activity [PMID: 10220893]. Homologues are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both Escherichia coli and Haemophilus influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain.

GO terms

Biological Process

GO:0006479 protein methylation

Molecular Function

GO:0008276 protein methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.