Family

Diphthine synthase (IPR004551)

Short name: Dphthn_synthase

Family relationships

None.

Description

Diphthine synthase (EC:2.1.1.98), also known as diphthamide biosynthesis S-adenosylmethionine-dependent methyltransferase, participates in the modification of a specific histidine residue in elongation factor 2 (EF-2) of eukaryotes and archaea to diphthamide. It is required for the methylation step in dipthamide biosynthesis.

This entry also includes diphthine methyl ester synthase (EC:2.1.1.314) from Saccharomyces cerevisiae (a product of the DPH5 gene), which is an S-adenosyl-L-methionine-dependent methyltransferase that catalyzes methylations of a modified histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester: the second step of diphthamide biosynthesis [PMID: 24739148].

GO terms

Biological Process

GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine

Molecular Function

GO:0004164 diphthine synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
TIGRFAMs
PIRSF
CDD
PANTHER