PA2G4 family (IPR004545)

Short name: PA2G4

Overlapping homologous superfamilies

Family relationships



Proteins of this family have been identified in a number of species as a nuclear protein with a cell cycle dependence. Various names have been given to members of this family which include cell cycle protein p38-2G4, also known as proliferation-associated protein PA2G4 [PMID: 7556453, PMID: 9345902], curved DNA-binding protein [PMID: 7985416], proliferation-associated protein A, and ErbB3-binding protein 1 (Ebp1) [PMID: 17690690]. They constitute the proliferation-associated PA2G4 family, which is structurally homologous to the type II methionine aminopeptidases, but without methionine aminopeptidase activity [PMID: 17765895, PMID: 17690690]. ErbB3 binding protein-1 (Ebp1) is a potential regulator of ErbB3 signaling, and is implicated in cell growth, apoptosis and differentiation in many cell types [PMID: 15073182, PMID: 24275324].

These proteins are classified as non-peptidase homologues in the MEROPS peptidase family M24 (clan MG).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.