Aspartate-tRNA synthetase, type 2 (IPR004523)

Short name: Asp-tRNA_synthase_2

Family relationships


Aspartyl tRNA synthetase is an alpha2 dimer that belongs to class IIb. Structural analysis combined with mutagenesis and enzymology data on the yeast enzyme point to a tRNA binding process that starts by a recognition event between the tRNA anticodon loop and the synthetase anticodon binding module [PMID: 10873455].

This family represents a group of aspartyl-tRNA synthetases from the eukaryotic cytosol, from archaea and from some bacteria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA (asn) is subsequently transamidated to Asn-tRNA (asn).

GO terms

Biological Process

GO:0006422 aspartyl-tRNA aminoacylation

Molecular Function

GO:0005524 ATP binding
GO:0004815 aspartate-tRNA ligase activity
GO:0000166 nucleotide binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.