Family

Heat shock protein HslU (IPR004491)

Short name: HslU

Overlapping homologous superfamilies

Family relationships

None.

Description

This family of proteins represent HslU, a bacterial clpX homologue, which is an ATPase and chaperone belonging to the AAA Clp/Hsp100 family and a component of the eubacterial proteasome.

ATP-dependent protease complexes are present in all three kingdoms of life, where they rid the cell of misfolded or damaged proteins and control the level of certain regulatory proteins. They include the proteasome in Eukaryotes, Archaea, and Actinomycetales and the HslVU (ClpQY, ClpXP) complex in other eubacteria. Genes homologous to eubacterial HslV, IPR001353, (ClpQ,) and HslU (ClpY, ClpX) have also been demonstrated in to be present in the genome of trypanosomatid protozoa. They are expressed as precursors, with a propeptide that is removed to produce the active protease. The protease is probably located in the kinetoplast (mitochondrion). Phylogenetic analysis shows that HslV and HslU from trypanosomatids form a single clad with other eubacterial homologues [PMID: 12446803].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0070011 peptidase activity, acting on L-amino acid peptides

Cellular Component

GO:0009376 HslUV protease complex
GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
PANTHER
TIGRFAMs