Helicase SMUBP-2/Hcs1-like (IPR004483)

Short name: SMUBP-2/Hcs1-like

Overlapping homologous superfamilies

Family relationships



Proteins in this entry belong to the DNA2/NAM7 helicase family, including SMUBP-2 from humans, DNA polymerase alpha-associated DNA helicase A (also konwn as Hcs1) from budding yeasts and some putative helicases from prokaryotes.

DNA-binding protein SMUBP-2 (also known as IGHMBP2, CATF1) is a 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction [PMID: 19158098]. It acts as a transcription regulator. It exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron [PMID: 11106437]. It binds to 5'-phosphorylated single-stranded guanine-rich DNA sequence related to the immunoglobulin mu chain switch region. It preferentially binds to the 5'-GGGCT-3' motif. It also interacts with tRNA-Tyr [PMID: 19158098]. In human, defects in IGHMBP2 are the cause of distal hereditary motor neuronopathy type 6 (HMN6); also known as spinal muscular atrophy distal autosomal recessive 1 (DSMA1) or spinal muscular atrophy with respiratory distress 1 (SMARD1) [PMID: 11528396].

Hcs1 may be involved in DNA replication [PMID: 9341218].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.