Domain

YjeF N-terminal domain (IPR004443)

Short name: YjeF_N_dom

Domain relationships

None.

Description

In bacteria or archaea, YjeF N-terminal domains occur either as single proteins or fused with other domains and are commonly associated with enzymes. YjeF N-terminal domains are often fused to a YjeF C-terminal domain. It is a bifunctional enzyme that catalyses the epimerisation of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP [PMID: 21994945].

Structurally, YjeF N-terminal domains represent a novel version of the Rossmann fold, one of the most common protein folds in nature. The YjeF N-terminal domain is comprised of a three-layer alpha-beta-alpha sandwich with a central beta-sheet surrounded by helices. This domain contains a putative catalytic site [PMID: 15257761].

The YjeF N-terminal domain is homologous to AIBP in mammals and YNL200C in budding yeasts. AIBP and YNL200C are NAD(P)H-hydrate epimerases that catalyses the epimerisation of the S- and R-forms of NAD(P)HX, at the expense of ATP, which is converted to ADP [PMID: 21994945].

Some proteins known to contain a YjeF N-terminal domain are listed below:

  • Escherichia coli hypothetical protein YjeF.
  • Thermotoga maritima hypothetical protein Tm0922.
  • Yeast uncharacterised protein YNL200C.
  • Yeast enhancer of mRNA-decapping protein 3 (EDC3).
  • Vertebrate enhancer of mRNA-decapping protein 3 (EDC3).
  • Mammalian apolipoprotein A-I binding protein (AI-BP).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
GENE3D
SUPERFAMILY
Pfam
HAMAP
PROSITE profiles