Family

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (IPR004417)

Short name: TrmFO

Family relationships

Description

Proteins in this entry catalyse the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs. They are closely related to GidA (glucose-inhibited division protein A, also known as MnmG), a protein involved in tRNA modification [PMID: 15509579, PMID: 11544186] in bacteria and mitochondria.

GO terms

Biological Process

GO:0008033 tRNA processing

Molecular Function

GO:0050660 flavin adenine dinucleotide binding
GO:0047151 methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PANTHER
HAMAP