Peptidase A31, coenzyme F420-reducing hydrogenase delta subunit (IPR004411)

Short name: Pept_A31_F420-red_hyd_d

Overlapping homologous superfamilies

Family relationships

  • Peptidase A31 family (IPR000671)
    • Peptidase A31, coenzyme F420-reducing hydrogenase delta subunit (IPR004411)


This group of sequence are classed as unassigned endopeptidases belonging to the MEROPS peptidase family A31 (HybD endopeptidase family, clan AE). The sequences in this family represent the delta subunit, FrhD, of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase, otherwise known as coenzyme F420-reducing hydrogenase. The delta subunit is not part of the active FRH heterotrimer, but is probably a protease required for maturation. The alpha subunit contains the metallo centre, which binds nickel. When nickel binds to the metallo centre the alpha subunit is processed to the active enzyme by cleavage at a conserved site near the C terminus. The delta subunit is thought to be responsible for these cleavages [PMID: 2207102].

GO terms

Biological Process

GO:0006464 cellular protein modification process

Molecular Function

GO:0008233 peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.