Translation release factor pelota (IPR004405)

Short name: Transl-rel_pelota

Overlapping homologous superfamilies

Family relationships


Pelota (known as DOM34 in yeast) binds Hbs1, which is EF1-alpha-related subfamily GTPase, and is considered to play a crucial role in mRNA surveillance for protein synthesis [PMID: 18022361]. It is involved in No-go decay (NGD) and non-stop decay (NSD) surveillance mechanisms that target mRNAs on which elongation complexes are stalled. Pelota/Hbs1 were shown to promote dissociation of stalled elongation complexes and release of intact peptidyl-tRNA in the presence of the ATP-binding cassette protein ABCE1 [PMID: 21448132]. Pelota is conserved in eukaryotes and archaea [PMID: 20974926].

GO terms

Biological Process

GO:0071025 RNA surveillance
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.