Domain

4-oxalocrotonate tautomerase (IPR004370)

Short name: 4-oxalocrotonate_tautomerase

Domain relationships

Description

4-Oxalocrotonate tautomerase,is an enzyme that converts 2-hydroxymuconate to the alpha-beta-unsaturated ketone, 2-oxo-3-hexenedioate [PMID: 1339435]. This enzyme forms part of a bacterial metabolic pathway that oxidatively catabolizes toluene, o-xylene, 3-ethyltoluene, and 1,2,4-trimethylbenzene into intermediates of the citric acid cycle. With a monomer size of just 62 amino acid residues, the 4-Oxalocrotonate tautomerase is one of the smallest enzyme subunits known [PMID: 12051677]. However, in solution, the enzyme forms a hexamer of six identical subunits, so the active site may be formed by amino acid residues from several subunits [PMID: 8547259]. This enzyme is also unusual in that it uses a proline residue at the amino terminus as an active site residue.

GO terms

Biological Process

GO:0006725 cellular aromatic compound metabolic process

Molecular Function

GO:0016853 isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
Pfam