Domain

Glyoxalase/fosfomycin resistance/dioxygenase domain (IPR004360)

Short name: Glyas_Fos-R_dOase_dom

Domain relationships

Description

Glyoxalase I (EC:4.4.1.5) (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid [PMID: 7684374]. Glyoxalase I is an ubiquitous enzyme which binds one mole of zinc per subunit. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric. The sequence of glyoxalase I is well conserved.

The domain represented by this entry is found in glyoxalase I and in other related proteins, including fosfomycin resistance proteins FosB [PMID: 11244082], FosA [PMID: 15741169], FosX [PMID: 17567049] and dioxygenases (eg. 4-hydroxyphenylpyruvate dioxygenase).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam