Domain

Thiaminase-2/PQQC (IPR004305)

Short name: Thiaminase-2/PQQC

Overlapping homologous superfamilies

Domain relationships

None.

Description

Proteins containing this domain are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TenA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase [PMID: 1898926] and has been identified as a Thiaminase 2 [PMID: 15709744]. The THI-4 protein, which is involved in thiamine biosynthesis, also contains this domain. The C-terminal part of these proteins consistently show significant sequence similarity to TenA proteins. This similarity was first noted with the Neurospora crassa THI-4 [PMID: 8662211].

This domain is also found in bacterial coenzyme PQQ synthesis protein C or PQQC. Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria [PMID: 12437981]. PQQC has been found to be required in the synthesis of PQQ, but its function is unclear.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam