Interleukin-12 alpha (IPR004281)

Short name: IL-12_alpha

Overlapping homologous superfamilies

Family relationships



Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, Measles virus and Human immunodeficiency virus 1 (HIV). IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit. On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses [PMID: 11422900, PMID: 9597139].

This entry represents interleukin-12 alpha.

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008083 growth factor activity
GO:0005143 interleukin-12 receptor binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.