Domain

Frog antimicrobial peptide, propeptide (IPR004275)

Short name: Frog_antimicrobial_propeptide

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

In addition to the highly specific cell-mediated immune system, vertebrates possess an efficient host-defence mechanism against invading microorganisms which involves the synthesis of highly potent antimicrobial peptides with a large spectrum of activity.

This entry represents the signal peptide and propeptide regions found in a number of these defence peptides secreted from the skin of amphibians, including caerins, dermaseptins, brevinin, dermorphin, tryptophillin, pleurain and phylloseptin [PMID: 18983817, PMID: 19272309]. This domain does not include the active peptides.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam