Domain

Dynein heavy chain region D6 P-loop domain (IPR004273)

Short name: Dynein_heavy_D6_P-loop

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains [PMID: 7866389]. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained [PMID: 11250194].

GO terms

Biological Process

GO:0007018 microtubule-based movement

Molecular Function

GO:0003777 microtubule motor activity

Cellular Component

GO:0030286 dynein complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam