Dynein heavy chain domain (IPR004273)

Short name: Dynein_heavy_dom

Overlapping homologous superfamilies


Domain relationships



Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Dynein is composed of a number of ATP-binding large subunits, intermediate size subunits and small subunits (see IPR001372). This family represents the C-terminal region of dynein heavy chain. The dynein heavy chain also exhibits ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules.

GO terms

Biological Process

GO:0007018 microtubule-based movement

Molecular Function

GO:0003777 microtubule motor activity

Cellular Component

GO:0030286 dynein complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.