Folate receptor (IPR004269)

Short name: Folate_rcpt

Overlapping homologous superfamilies


Family relationships


Folic acid and its reduced derivatives are transported via two widely expressed transporters, the reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT), and via a family of glycosyl-phosphatidylinositol (GPI)-anchored receptors with limited expression profiles known as folate receptors (FRs) [PMID: 23934049].

Folate receptors (FR) are high affinity receptors that transport folate via endocytosis. Human FR exists in three isoforms, alpha and beta equipped with GPI anchors, and gamma not possessing a GPI anchor [PMID: 8839936].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.