AdipoR/Haemolysin-III-related (IPR004254)

Short name: AdipoR/HlyIII-related

Overlapping homologous superfamilies


Family relationships

  • AdipoR/Haemolysin-III-related (IPR004254)


Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus [PMID: 7495855]. YOL002c (AdipoR-like receptor IZH2) from Saccharomyces cerevisiae encodes a protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism [PMID: 11916977, PMID: 15664187]. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adiponectin (AdipoQ) receptors (AdipoR), and hence have been named PAQR proteins [PMID: 16044242]. The mammalian members include progesterone binding proteins [PMID: 17082257]. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.