Autophagy protein Atg8 ubiquitin-like (IPR004241)

Short name: Atg8-like

Overlapping homologous superfamilies

Family relationships


A number of autophagy-related proteins have been identified in yeast, including the key autophagic protein Atg8, which is a ubiquitin-like protein with a structure consisting of two amino-terminal alpha-helices and a ubiquitin-like core [PMID: 18508918, PMID: 15265004]. Many other eukaryotes contain multiple Atg8 orthologues. Atg8 genes of multicellular animals can be divided into three subfamilies: microtubule-associated protein 1 light chain 3 (MAP1LC3 or LC3) [PMID: 7908909], gamma-aminobutyric acid receptor-associated protein (GABARAP) and Golgi-associated ATPase enhancer of 16 kDa (GATE-16) [PMID: 21867568, PMID: 20562859]. Family members are involved in diverse intracellular trafficking and autophagy processes.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.