5-carboxymethyl-2-hydroxymuconate isomerase (IPR004220)

Short name: 5-COMe_2-OHmuconate_Isoase

Overlapping homologous superfamilies

Family relationships



5-carboxymethyl-2-hydroxymuconate isomerase transforms 5-carboxymethyl-2-hydroxy-muconic acid into 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid during the third step of the homoprotocatechuate catabolic pathway [PMID: 2194841]. Homoprotocatechuate (HPC; 3,4-dihydroxyphenylacetate) is catabolized to Krebs cycle intermediates via extradiol (meta-) cleavage and the necessary enzymes are chromosomally encoded in a variety of bacteria [PMID: 8384293]. 5-carboxymethyl-2-hydroxymuconate isomerase is probably a dimer of two identical subunits [PMID: 2194841]. A comparison of the N-terminal half of the isomerase/decarboxylase sequence from the pathway (both encoded by the gene hpcE), with the second half showed significant similarity. This suggests that a duplication may have occurred to produce a bifunctional gene [PMID: 8223600].

GO terms

Biological Process

GO:0019439 aromatic compound catabolic process

Molecular Function

GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.