Prokaryotic glutathione synthetase, ATP-binding (IPR004218)

Short name: GSHS_ATP-bd

Overlapping homologous superfamilies


Domain relationships

  • ATP-grasp fold (IPR011761)
    • Prokaryotic glutathione synthetase, ATP-binding (IPR004218)


Prokaryotic glutathione synthetase EC: (glutathione synthase) catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to orthophosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis. The enzyme is inhibited by 7,8-dihydrofolate, methotrexate and trimethoprim. This is the ATP-binding domain of the enzyme.

GO terms

Biological Process

GO:0006750 glutathione biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0004363 glutathione synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.