Homologous Superfamily

L-fucose/L-arabinose isomerase, C-terminal (IPR004216)

Short name: Fuc/Ara_isomerase_C

Description

L-fucose isomerase (EC:5.3.1.25) converts the aldose L-fucose into the corresponding ketose L-fuculose during the first step in fucose metabolism using Mn2+ as a cofactor. The enzyme is a hexamer, forming the largest structurally known ketol isomerase, and has no sequence or structural similarity with other ketol isomerases. The structure was determined by X-ray crystallography at 2.5 A resolution [PMID: 9367760].

L-arabinose isomerase (AraA) (EC:5.3.1.4) catalyses the conversion of L-arabinose to L-ribulose as the first step in the pathway of L-arabinose utilization as a carbon source [PMID: 9084180].

L-arabinose isomerase adopts a protein fold most similar to fucose isomerase despite low sequence identity [PMID: 16756997]. This entry represents a C-terminal structural domain common to L-fucose and L-arabinose isomerases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D