Domain

Bacteriophage Mu, transposase (IPR004189)

Short name: Phage_Mu_transposase

Overlapping homologous superfamilies

Domain relationships

None.

Description

This transposase is essential for integration, replication-transposition and excision of Bacteriophage Mu DNA. Transposition requires transposase and a transposition enhancer, and the DNA can be transposed into multiple sites in bacterial genomes.

The crystal structure of the core domain of Mu transposase, MuA, has been determined. The first of two subdomains contains the active site and, despite very limited sequence homology, exhibits a striking similarity to the core domain of Human immunodeficiency virus 1 integrase. The enzymatic activity of MuA is known to be activated by formation of a DNA-bound tetramer of the protein [PMID: 7628012].

GO terms

Biological Process

GO:0015074 DNA integration
GO:0006313 transposition, DNA-mediated

Molecular Function

GO:0003677 DNA binding
GO:0004803 transposase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam