Domain

Epstein Barr virus nuclear antigen-1, DNA-binding (IPR004186)

Short name: EBNA1_DNA-bd

Overlapping homologous superfamilies

Domain relationships

None.

Description

The Epstein-Barr virus (strain GD1) nuclear antigen 1 (EBNA1) binds to and activates DNA replication from the latent origin of replication. The crystal structure of the DNA-binding and dimerization domains were solved [PMID: 7553871], and it was found that EBNA1 appears to bind DNA via two independent regions, the core and the flanking DNA-binding domains. This DNA-binding domain has a ferredoxin-like fold.

GO terms

Biological Process

GO:0006260 DNA replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0006275 regulation of DNA replication

Molecular Function

GO:0003677 DNA binding
GO:0003688 DNA replication origin binding

Cellular Component

GO:0042025 host cell nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
Pfam