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Overview
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Pathways & interactions
Epstein Barr virus nuclear antigen-1, DNA-binding (IPR004186)
Short name: EBNA1_DNA-bd
Overlapping homologous superfamilies
- E2/EBNA1, C-terminal (IPR035975)
- Epstein Barr virus nuclear antigen-1, DNA-binding domain superfamily (IPR037007)
Domain relationships
None.
Description
The Epstein-Barr virus (strain GD1) nuclear antigen 1 (EBNA1) binds to and activates DNA replication from the latent origin of replication. The crystal structure of the DNA-binding and dimerization domains were solved [PMID: 7553871], and it was found that EBNA1 appears to bind DNA via two independent regions, the core and the flanking DNA-binding domains. This DNA-binding domain has a ferredoxin-like fold.
GO terms
Biological Process
GO:0006260 DNA replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0006275 regulation of DNA replication
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
Cellular Component
GO:0042025 host cell nucleus