Spider toxin (IPR004169)

Short name: Spidertoxin

Overlapping homologous superfamilies


Family relationships



This family contains spider toxins that include the omega-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta [PMID: 8241166,PMID: 8232218], as well as purotoxin-1 (PT1), a spider peptide venom of the Central Asian spider Geolycosa sp., which specifically exerts inhibitory action on P2X3 purinoreceptors at nanomolar concentrations [PMID: 20437566]. These spider toxins, which are ion channel blockers, share a common structural motif composed of a triple-stranded antiparallel beta-sheet, stabilized by internal disulfide bonds known as cystine knots [PMID: 7703698].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0008200 ion channel inhibitor activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.