Repeat

PPAK motif (IPR004168)

Short name: PPAK_motif

Description

PPAK is a repeated protein motif found in the PEVK (Pro-Glu-Val-Lys) domain of the titin protein and in a number of other proteins. Titin (EC:2.7.11.1) is a giant elastic protein found in striated muscle that is a key component in the assembly and functioning of sarcomeres [PMID: 15507486]. PPAK motifs (PPAK refers to the four amino acids found at the beginning of the motif) occur 60 times in human soleus titin [PMID: 11276084]. PPAK motifs occur in groups of 2-12 that are separated by regions rich in glutamic acid (approximately 45%) and termed polyE segments. The charge fluctuation between the PPAK and polyE regions suggests ionic interactions between these segments and their involvement in the elastic function of titin.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam