Domain

UbiB domain (IPR004147)

Short name: UbiB_dom

Domain relationships

Description

This entry represents a domain found in Escherichia coli UbiB, known in Providencia stuartii as Aarf, which is required for ubiquinone (CoQ) biosynthesis [PMID: 10960098, PMID: 9422602, PMID: 23709220]. Some proteins with this domain are described as aarF domain-containing protein kinases (ADCKs). This domain is also found in yeast ABC1 proteins (P27697) required for function of the mitochondrial bc1 complex [PMID: 1648478], in which CoQ functions as an essential cofactor.

The function of these proteins is not clear. Along with ABC1, UbiB is part of a large family of proteins that contain motifs found in eukaryotic-type protein kinases [PMID: 9799791], but is not known if they have kinase activity and how this would relate to their requirement for the monoxygenase step in CoQ synthesis. A role in regulation of this step by phosphorylation has been speculated [PMID: 10960098].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam