DAN (IPR004133)

Short name: DAN

Overlapping homologous superfamilies

Domain relationships



This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family [PMID: 9660951] after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signalling. It is postulated that all members of this family antagonize different TGF beta TGF-beta ligands [PMID: 9660951].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.