GPN-loop GTPase (IPR004130)

Short name: Gpn

Overlapping homologous superfamilies

Family relationships


Proteins in this entry belong to the GPN-loop GTPase family [PMID: 17468740], including Npa3 (also known as Gpn1) and Gpn2/3 from budding yeasts. In humans, Npa3 homologue is known as XAB1; Gpn2 is known as GPN2/ATPBD1B; Gpn3 is known as Parcs.

Npa3 plays an important part in transporting RNA polymerase II (RNAPII) to the nucleus. The binding of Npa3 with RNAPII is GTP-dependent [PMID: 21844196]. Gpn2 and Gpn3 are putative GTPase that have a role in biogenesis of RNA polymerase II and III [PMID: 23267056]. Npa3, Gpn2 and Gpn3 is involved in sister chromatid cohesion [PMID: 21532343, PMID: 23324351].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.