THUMP domain (IPR004114)

Short name: THUMP_dom

Overlapping homologous superfamilies


Domain relationships



The THUMP (after thiouridine synthases, RNA methylases and pseudouridine synthases) domain is a module of 100-110 amino acid residues which is involved RNA metabolism. It is shared by enzymes that are predicted to carry out at least three unrelated types of RNA-modification, namely methylation, pseudouridylation and thiouridylation. The THUMP domain can occur in stand- alone form or in association with a variety of catalytic domains, like methylase, pseudo U-synthase or rhodanese. THUMP is an ancient domain with predicted RNA-binding capacity that probably functions by delivering a variety of RNA modification enzymes to their targets. The THUMP domain apparently evolved prior to the divergence of the primary divisions of life [PMID: 11295541].

The THUMP domain has been predicted to adopt an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8 [PMID: 11295541].

Some proteins known to contain a THUMP domain are listed below:

  • Bacterial and archaeal thiI-like 4-thiouridine synthases.
  • Bacterial, archaeal and eukaryotic RNA methylases.
  • Archaeal pseudouridine synthases (PSUSs).
  • Several uncharacterised proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles