Prp18 (IPR004098)

Short name: Prp18

Overlapping homologous superfamilies


Domain relationships



The splicing factor Prp18 is required for the second step of pre-mRNA splicing. PRP18 appears to be primarily associated with the U5 snRNP.

The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known [PMID: 10737784]. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles [PMID: 10737784].

GO terms

Biological Process

GO:0008380 RNA splicing

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005681 spliceosomal complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.