Fungal ribotoxin (IPR004025)

Short name: Fun_ribotoxin

Overlapping homologous superfamilies

Family relationships


The fungal ribotoxins are a family of highly specific ribonucleases that inactivate the ribosome by cleavage of the 23-28S RNA of the large ribosomal subunit at a single phosphodiester bond. Cleavage abolishes the capacity of ribosomes to carry out protein synthesis by inhibiting elongation factor 1- dependent binding of aminoacyl-tRNA and GTP-dependent binding of elongation factor 2 to ribosomes. Mitogillin-like ribotoxins are among the most potent inhibitors of translation so far identified, and they have been investigated as potential anti-tumour agents, or components of immunotoxins [PMID: 10212236]. Members of this family include ribonuclease mitogillin, ribonuclease alpha-sarcin and ribonuclease clavin precursor proteins.

GO terms

Biological Process

GO:0017148 negative regulation of translation

Molecular Function

GO:0003723 RNA binding
GO:0004540 ribonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.