Mago nashi protein (IPR004023)

Short name: Mago_nashi

Overlapping homologous superfamilies

Family relationships



This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene [PMID: 1765008]. The protein is an integral member of the exon junction complex (EJC). The EJC is a multiprotein complex that is deposited on spliced mRNAs after intron removal at a conserved position upstream of the exon-exon junction, and transported to the cytoplasm where it has been shown to influence translation, surveillance, and localization of the spliced mRNA. It consists of four core proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP and is supposed to be a binding platform for more peripherally and transiently associated factors along mRNA travel. Mago and Y14 form a stable heterodimer that stabilizes the complex by inhibiting eIF4AIII's ATPase activity. Mago-Y14 heterodimer has been shown to interact with the cytoplasmic protein PYM, an EJC disassembly factor, and specifically binds to the karyopherin nuclear receptor importin 13 [PMID: 18164611, PMID: 20818392, PMID: 20946982, PMID: 15734573, PMID: 12781131, PMID: 15145352, PMID: 18423193, PMID: 1765008, PMID: 10656761, PMID: 10662555, PMID: 11707413, PMID: 9272960, PMID: 12730685, PMID: 14968132, PMID: 15567724, PMID: 16380844, PMID: 17545126].

The human homologue has been shown to interact with an RNA binding protein, ribonucleoprotein rbm8 (Q9Y5S9) [PMID: 10662555]. An RNAi knockout of the Caenorhabditis elegans homologue causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination [PMID: 10656761] but the protein is also found in hermaphrodites and other organisms without a sexual differentiation.

GO terms

Biological Process

GO:0008380 RNA splicing

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0035145 exon-exon junction complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.