Domain

RUN domain (IPR004012)

Short name: Run_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The RUN domain, named after RPIP8, unc-14 and NESCA, is organised into six conserved blocks (A-F), which are predicted to constitute the 'core' of a globular structure tolerating insertions of considerable length between the conserved blocks. The RUN domain is found in one or two copies in several proteins that are linked particularly to the functions of GTPases in the Rap and Rab families. RUN domains can be associated with TBC/rab GAP, FYVE, DENN, SH3, DAG/PE-binding, PLAT/LH2, PH or PX domains. The RUN domain may have a role in the interaction of various proteins with cytoskeletal filaments [PMID: 11509568].

The predicted secondary structures of the RUN domain core indicate a predominantly alpha fold [PMID: 11166556].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
SMART
Pfam