Ubiquitously expressed transcript protein UXT (IPR003994)
Short name: UXT
Overlapping homologous superfamilies
- Prefoldin (IPR009053)
- Prefoldin alpha-like (IPR004127)
- Ubiquitously expressed transcript protein UXT (IPR003994)
Ubiquitously expressed transcript protein UXT is involved in gene transcription regulation. It acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). It is an AR N terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation [PMID: 11854421].
It is a protein which interacts with the N terminus of the Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21. DSCR1 interacts with calcineurin and is overexpressed in Down's syndrome patients. UXT, which is encoded in human Xp11, is a 157-amino acid protein present in both cytosol and nucleus of the cells [PMID: 15264020].
The members of this family are related to prefoldin, which is part of a molecular chaperone system that promotes the correct folding of nascent polypeptide chains. Prefoldin interacts with the nascent chain to stabilise it prior to its folding within the central cavity of a chaperonin. Prefoldin is a hexamer consisting of two types of subunits, alpha and beta. Archaeal prefoldin contains one type of alpha and one type of beta subunit [PMID: 11106732], while eukaryotic prefoldin contains two different but related alpha subunits and four related beta subunits [PMID: 12456645].
- PR01502 (UXTPROTEIN)