Family

Potassium channel, voltage dependent, KCNQ (IPR003937)

Short name: K_chnl_volt-dep_KCNQ

Family relationships

Description

KCNQ channels (also known as KQT-like channels) differ from other voltage-gated 6 TM helix channels, chiefly in that they possess no tetramerisation domain. Consequently, they rely on interaction with accessory subunits, or form heterotetramers with other members of the family [PMID: 10838601]. Currently, 5 members of the KCNQ family are known. These have been found to be widely distributed within the body, having been shown to be expressed in the heart, brain, pancreas, lung, placenta and ear. They were initially cloned as a result of a search for proteins involved in cardiac arhythmia. Subsequently, mutations in other KCNQ family members have been shown to be responsible for some forms of hereditary deafness [PMID: 8528244] and benign familial neonatal epilepsy [PMID: 9430594].

GO terms

Biological Process

GO:0006813 potassium ion transport

Molecular Function

GO:0005249 voltage-gated potassium channel activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS