Epithelial membrane protein 2 (IPR003933)

Short name: EMP-2

Overlapping homologous superfamilies


Family relationships


The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities [PMID: 7499407]. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length, and shares a common predicted transmembrane (TM) topology of 4 TM domains, with intracellular N- and C-termini [PMID: 8884260].

A role for the EMP family members in the control of cell growth has been suggested [PMID: 7499407]. EMP-1 is expressed at high levels in proliferating cells, and at reduced levels in cells undergoing growth arrest [PMID: 8996089]. In contrast, PMP22, which is co-expressed with EMP-1 in a range of tissues, displays an inverse pattern of regulation, with high levels of expression in cultured cells undergoing growth arrest [PMID: 8996089]. It has therefore been proposed that these proteins may have reciprocal functions in the control of cell quiescence and proliferation.

EMP-2, previously termed XMP, was identified by expressed sequence tag (EST) database searching, pursuing sequences similar to EMP-1 [PMID: 8917086]. Mus musculus (Mouse) and Homo sapiens (Human) isoforms have been cloned. EMP-2 is expressed in a range of tissues, including ovary, heart, lung and intestine. Although its function has not been elucidated, it has been postulated that EMP-2 may be involved in the regulation of cell proliferation on the basis of its sequence similarity to EMP-1 [PMID: 8917086].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.