Claudin-16 (IPR003927)

Short name: Claudin16

Family relationships


Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [PMID: 21372174, PMID: 20188437, PMID: 24665401]. They can also form heteropolymers with each other within and between tight junction strands [PMID: 10562289]. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 [PMID: 24665401]. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [PMID: 24665401].

Claudin-16 was originally termed paracellin-1. It was re-classified as claudin-16 on the basis of its sequence similarity to the claudin family [PMID: 10810088]. Claudin-16 is involved in renal paracellular Mg2+ resorption and is required for selective paracellular conductance [PMID: 10390358]. Defects in the claudin-16 gene are associated with an autosomal recessive chronic interstitial nephritis with diffuse zonal fibrosis (CINF) [PMID: 10810088, PMID: 10390358].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

GO:0005923 bicellular tight junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.