Domain

NIDO domain (IPR003886)

Short name: NIDO_dom

Domain relationships

None.

Description

The ~180-residue NIDO domain is an extracellular domain of unknown function, found in nidogen (entactin) and hypothetical proteins. The NIDO domain is found in association with other domains, such as nidogen G2 beta-barrel (IPR006605), thyroglobulin type-1 (IPR000716), LDLRB (IPR000033), AMOP (IPR005533), EGF-like (IPR000742), VWFD, IPT/TIG, or sushi/CCP/SCR (IPR000436) [PMID: 11893501, PMID: 12084055, PMID: 15053982, PMID: 16500040].

Some proteins known to contain a NIDO domain are listed below:

  • Vertebrate nidogen-1 (NID-1) or entactin, a sulphated glycoprotein widely distributed in basement membranes.
  • Vertebrate nidogen-2 (NID-2) or osteonidogen, a cell adhesion glycoprotein which is widely distributed in basement membranes.
  • Vertebrate alpha-tectorin.
  • Mammalian mucin-4 (MUC4), a highly glycosylated membrane-bound protein.
  • Xenopus ID14, a putative matrix protein.

GO terms

Biological Process

GO:0007160 cell-matrix adhesion

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART
PROSITE profiles