Family

Beta-1,4-galactosyltransferase (IPR003859)

Short name: Galactosyl_T

Family relationships

None.

Description

Beta-1,4-galactosyltransferase is responsible for catalysing the transfer of galactose onto proteins or lipids [PMID: 10580128]. Studies on C.elegans have shown that the enzyme is required for susceptibility to pore-forming crystal toxins, together with glycosyltransferase genes bre-1, bre-2, bre-3 and bre-5 [PMID: 12944392].

In mammals, the protein is found in long and short forms. The short form is preferentially located in the golgi complex [PMID: 1714903], where it catalyses the production of lactose in the lactating mammary gland; it may also be responsible for the synthesis of complex-type N-linked oligosaccharides of various glycoproteins, as well as the carbohydrate moieties of glycolipids. The short form is preferentially targeted to the plasma membrane of many cell types [PMID: 1714903], where it functions as a recognition molecule during various cell-cell and cell-matrix interactions, by binding to specific oligosaccharide ligands on opposing cells, or in the extracellular matrix.

This entry also includes other members of the glycosyltransferase 7 family, such as xylosylprotein 4-beta-galactosyltransferase and beta-N-acetyl-D-glucosaminide beta-1,4-N-acetylglucosaminyl-transferase.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0016757 transferase activity, transferring glycosyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
PANTHER